Interferon lambda inhibits dengue virus replication in epithelial cells
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چکیده
منابع مشابه
Chloroquine Inhibits Dengue Virus Type 2 Replication in Vero Cells but Not in C6/36 Cells
Dengue viruses are the most important arthropod-borne viruses in terms of morbidity and mortality in the world. Since there is no dengue vaccine available for human use, we have set out to investigate the use of chloroquine as an antiviral drug against dengue. Chloroquine, an amine acidotropic drug known to affect intracellular exocytic pathways by increasing endosomal pH, was used in the in vi...
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DDRC, Queen Mary’s School of Medicine and Dentistry, Newark Street, London E1 2AD, UK; Department of Pathology and Microbiology, University of Bristol, University Walk, Bristol BS8 1TD, UK; Department of Gastroenterology and Hepatology, University Hospital of Essen, Hufelandstr. 55, 45122 Essen, Germany; Centre for Hepatology, Royal Free & University College Medical School, Rowland Hill Street,...
متن کاملExtract of Scutellaria baicalensis inhibits dengue virus replication
BACKGROUND Scutellaria baicalensis (S. baicalensis) is one of the traditional Chinese medicinal herbs that have been shown to possess many health benefits. In the present study, we evaluated the in vitro antiviral activity of aqueous extract of the roots of S. baicalensis against all the four dengue virus (DENV) serotypes. METHODS Aqueous extract of S. baicalensis was prepared by microwave en...
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conclusions lrrfip1 and its mediated production of type i interferon play a role in controlling hcv infection. the findings of this study provide new target for hcv treatment and contribute to development of anti-hcv drugs. results lrrfip1 increased the expression of ifn-β in hepatocytes with or without hcv infection. induction of ifn-β by lrrfip1 was enhanced with the presence of hepatitis c v...
متن کاملLet-7c overexpression inhibits dengue virus replication in human hepatoma Huh-7 cells.
MicroRNAs (miRNAs) constitute an important class of non-coding RNA implicated in gene expression regulation. More than 1900 miRNA molecules have been identified in humans and their modulation during viral infection and it is recognized to play a role in latency regulation or in establishing an antiviral state. The liver cells are targets during DENV infection, and alteration of liver functions ...
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ژورنال
عنوان ژورنال: Virology Journal
سال: 2015
ISSN: 1743-422X
DOI: 10.1186/s12985-015-0383-4